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Take rosiglitazone exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Rosiglitazone can be taken with or without food or meals. It is important to take rosiglitazone regularly to get the most benefit. Your doctor may want you to have blood or urine tests or other medical evaluations during treatment with rosiglitazone to monitor blood sugar levels, liver function, or other factors. Usually, liver function is monitored with blood tests at the start of treatment, every two months for the first year of treatment, and periodically thereafter during treatment with rosiglitazone. Notify your doctor immediately if you develop nausea, vomiting, abdominal pain, unusual fatigue, loss of appetite, yellow skin or eyes, or dark urine. Although rosiglitazone does not usually cause hypoglycemia (low blood sugar), hypoglycemia may result from skipped meals, excessive exercise, or alcohol consumption. Know the signs and symptoms of hypoglycemia, which include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea. Carry a piece of non-dietetic hard candy or glucose tablets with you to treat episodes of low blood sugar.

If you experience any of the following serious side effects, stop taking rosiglitazone and seek emergency medical attention or notify your doctor immediately: * an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); * nausea, vomiting, abdominal pain, or loss of appetite; * unusual fatigue; * yellowing of the skin or eyes; or * dark urine. Notify your doctor immediately if you experience an unusually rapid increase in weight or edema (swelling, water retention), shortness of breath, or chest pain during treatment with rosiglitazone. Although rosiglitazone does not usually cause hypoglycemia (low blood sugar), hypoglycemia may result from skipped meals, excessive exercise, or alcohol consumption. Know the signs and symptoms of hypoglycemia, which include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea. Carry a piece of hard non-dietetic candy or glucose tablets with you to treat episodes of low blood sugar. Other less serious side effects may also occur. Continue to take rosiglitazone and talk to your doctor if you experience: * headache; or * sore throat, nasal discharge, or cold symptoms. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

No drugs have been reported to interact with rosiglitazone although interactions may exist. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Take the missed dose as soon as you remember. If you do not remember until the next day, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose.

Store rosiglitazone at room temperature away from moisture and heat.